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Meanwhile, a cluster RCT in Bangladesh found a statistically significant 9% reduction in symptomatic seroprevalence in villages where surgical masks were provided and their use promoted.
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A trial conducted in Denmark found no statistically significant difference in infection rates between the group provided with and urged to wear surgical masks and a control group. Aside from vaccines and therapeutics, the only exceptions to date are two RCTs of masks. One limitation of this review is the paucity of data from randomized controlled trials (RCTs) to measure the efficacy and effectiveness of COVID-19 prevention interventions.
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1).Įvidence-based recommendations for 10 key COVID-19 policy and strategic areas. Accordingly, we review the available evidence regarding 10 key policy areas for which we recommend modification or refinement (Fig. While vaccination has ushered in great hope, the time is ripe to revisit the assumptions underlying some current interventions and to implement more context-sensitive, evidence-based policies. COVID-19 vaccines have proven to be highly effective at preventing severe disease and mortality and, to a lesser extent, milder symptomatic and asymptomatic cases. As the international vaccination rollout continues to expand, we call for a reexamination of existing mitigation approaches to adapt to emerging evidence on effectiveness and to minimize unintended consequences. By late October 2021, over 245 million confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection cases and over 4.9 million related deaths had been reported globally. The coronavirus disease 2019 (COVID-19) pandemic has caused devastating loss of life and disrupted healthcare systems and daily life globally. The Creative Commons Public Domain Dedication waiver ( ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.